• 陽明大學醫學工程研究所博士
• 台灣大學醫學系學士

• 馬偕紀念醫院骨科資深主治醫師
• 聖約翰科技大學休健系兼任助理教授
• 陽明大學醫學系兼任助理教授

骨科學、醫學工程概論、PBL

骨科、醫學工程

1. Nguyen DPC, Chang TK*, Nguyen BT, Lai KY, Chen HT, Fong YC, Liaw CC, Tang CH.  The natural compound ugonin V targets MMP7 production and restricts chondrosarcoma metastasis by suppressing the MEK/ERK/c-Jun signaling pathways.. Journal of Functional Foods. Vol.117:e106255. Jun. 2024. (SCI/SCIE) ( SDGs3)
2. Chien KT, Chen YC, Chang TK, Liu YC, Chen LP, Huang YC, Lian YS, Li JY.  Novel cervical endoscopic unilateral laminoforaminotomy for bilateral decompression in cervical spondylosis myeloradiculopathy: A technical note and clinical results.. Journal of Clinical Medicine. Vol.13-No.7:e1970. Mar. 2024. (SCI/SCIE) ( SDGs3)
3. Fang WS, Chang TK*.  Failure Risks of Bracing Treatment in Adolescent Idiopathic Scoliosis.. Formosan Journal of Musculoskeletal Disorders. Vol.15(1):17-21. Mar. 2024. (其他具同儕審查機制之期刊) ( SDGs3)
4. Tsai PC, Liu YC, Chang TK, Chen LP, Huang YC, Lian YS, Chien KT.  The novel Kambin Torpedo full-endoscopic lumbar interbody fusion technique: a case series.. European Spine Journal. Vol.33-No.2:417-428. Feb. 2024. (SCI/SCIE) ( SDGs3)
5. Huang YC, Chen WC, Yu CL, Chang TK, Wei IC, Chang TM, Liu JF, Wang SW.  FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.. BIOCHEMICAL PHARMACOLOGY. Vol.218:e115853. Dec. 2023. (SCI/SCIE) ( SDGs3)
6. Ko CY, Lin YY, Achudhan D, Chang JY, Liu SC, Lai CY, Huang YL, Tsai CH, Fong YC, Chen HT, Lee KT, Huang CC, Chang TK**, Tang CH*.  Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization.. International Journal of Biological Sciences. Vol.19-No.16:5275-5289. Oct. 2023. (SCI/SCIE) ( SDGs3)
7. Nguyen BT, Lin CY, Chang TK, Fong YC, Thadevoos LA, Lai CY, Huang YL, Tsai CH, Ko CY, Liu JF, Yang SF, Tang CH.  Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR-520f-3p production and suppressing MMP7 expression.. JOURNAL OF PINEAL RESEARCH. Vol.75-No.1:e12872. Aug. 2023. (SCI/SCIE) ( SDGs3)
8. Chang TK*, Huang YC, Tzeng ST.  Pediatric Kyphosis.. Journal of Musculoskeletal Research. Vol.26(2):234008-1-234008-7. Jun. 2023. (其他具同儕審查機制之期刊) ( SDGs3)
9. Lu YC, Hsu LI, Lin CF, Hsu CP, Chang TK, Cheng CC, Huang CH.  Biomechanical characteristics of self-expanding sinus stents during crimping and deployment-A comparison between different biomaterials.. Journal of the Mechanical Behavior of Biomedical Materials. Vol.138:e105669. Feb. 2023. (SCI/SCIE) ( SDGs3)
10. Wang YH, Tsai CH, Liu SC, Chen HT, Chang JY, Ko CY, Hsu CJ, Chang TK*, Tang CH.  miR-150-5p and XIST interaction controls monocyte adherence: Implications for osteoarthritis therapy.. Frontiers in Immunology. Vol.13:e1004334. Sep. 2022. (SCI/SCIE) ( SDGs3)
11. Lu YC, Chang TK, Lin TC, Yeh ST, Fang HW, Huang CH, Huang CH.  The potential role of herbal extract Wedelolactone for treating particle-induced osteolysis: an in vivo study.. Journal of Orthopaedic Surgery and Research. Vol.17-No.1:e335. Jun. 2022. (SCI/SCIE) ( SDGs3)
12. Lu YC, Chang TK, Yeh ST, Lin TC, Lin HS, Chen CH, Huang CH, Huang CH.  Evaluation of graphene-derived bone scaffold exposure to the calvarial bone_in-vitro and in-vivo studies. Nanotoxicology. Vol.16-No.1:1-15. Feb. 2022. (SCI/SCIE) ( SDGs3)
13. Chang TK, Zhong TH, Liu SC, Huang CC, Tsai CH, Lee HP, Wang SW, Hsu CJ, Tang CH.  Apelin promotes endothelial progenitor cell angiogenesis in rheumatoid arthritis disease via the miR-525-5p/angiopoietin-1 pathway. Frontiers in Immunology. Vol.12:e737990. Sep. 2021. (SCI/SCIE) ( SDGs3)
14. Chi-Hsin Lin, Yuan-Ching Chang, Ting-Kuo Chang, Chang-Hung Huang, Yung-Chang Lu, Chun-Hsiung Huang, Ming-Jen Chen.  Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway. LIFE SCIENCES. Vol.265:e118832. Jan. 2021. (SCI/SCIE) ( SDGs3)
15. Chang-Hung Huang, Yung-Chang Lu,  Lin-I Hsu, Jiann-Jong Liau, Ting-Kuo Chang, Chun-Hsiung Huang.  Effect of material selection on tibial post stresses in posterior-stabilized knee prosthesis. Bone and Joint Research. Vol.9-No.11:768-777. Nov. 2020. (SCI/SCIE) ( SDGs3)
16. Huang YC, Chang TK*.  Bosworth fracture treated with immediate open reduction and internal fixation 6 hours after injury: A case report.. Formosan Journal of Musculoskeletal Disorders. Vol.11-No.3:136-140. Aug. 2020. (其他具同儕審查機制之期刊) ( SDGs4)
17. Ting-Kuo Chang,  Yu-Han Wang, Shu-Jui Kuo, Shih-Wei Wang, Chun-Hao Tsai,  Yi-Chin Fong, Nan-Lin Wu, Shan-Chi Liu, Chih-Hsin Tang.  Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways. Aging-US. Vol.12-No.10:9224-9239. May. 2020. (SCI/SCIE) ( SDGs3)
18. TK CHANG, YC Lu, ST Yeh, TC Lin, CH Huang, CH Huang.  In vivo and in vitro biological responses to graphene and graphene oxide-A murine calvarial animal study.. International Journal of Nanomedicine. Vol.15:647-659. Jan. 2020. (SCI/SCIE)
19. CY Yang, C Chen, CY Lin, YH Chen, CY Lin, CW Chi, YJ Chen, SC Liu, TK Chang, CH Tang, YW Lai, HJ Tsai, JJ Chen, SW Wang.  Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTORdependent pathways in human endothelial progenitor cells. PHYTOMEDICINE. Vol.64:e152911. Nov. 2019. (SCI/SCIE)
20. Ting-Kuo Chang, Ching-Chi Hsu , Ming-An Yang , Devina Sutaji.  Effects of Fusion Device Designs on Spine Biomechanics Computational simulation for smart health care. IEEE Consumer Electronics Magazine. Vol.8-No.2:84-89. Mar. 2019. (SCI/SCIE)
21. Ting-Kuo Chang, Ching-Chi Hsu.  Comparison of Different Pullout Test Setups for Evaluation of Bone-Implant Interfacial Strength of Anterior Lumbar Interbody Fusion Devices. Journal of Medical and Biological Engineering. Vol.39-No.1:117-125. Feb. 2019. (SCI/SCIE)
22. Yu-Ching Huang, Tsung-Yu Lin, Te-Yang Huang, Ting-Kuo Chang, Guo-Shou Wang.  Excessive valgus alignment leading to asymmetric wear of tibia bearing polyethylene and bush in a rotating hinge knee prosthesis for proximal tibial tumor resection. Formosan Journal of Musculoskeletal Disorders. Vol.9-No.4:176-180. Nov. 2018. (其他具同儕審查機制之期刊)
23. Lu YC, Wu CY, Chang TK, Huang CH, Huang CH.  Elastoplastic behavior of highly cross-linked and vitamin E-stabilized polyethylene - A biomechanical study. Clinical Biomechanics. Vol.59:152-158. Nov. 2018. (SCI/SCIE)
24. Huang CH, Hsu LI, Chang TK, Chuang TY, Shih SL, Lu YC, Chen CS, Huang CH.  Stress distribution of the patellofemoral joint in the anatomic V-shape and curved dome-shape femoral component: a comparison of resurfaced and unresurfaced patellae. Knee Surgery, Sports Traumatology, Arthroscopy. Vol.25-No.1:263-272. Jan. 2017. (SCI/SCIE)
25. Kao MH, Tsai YF, Chang TK, Wang JS, Chen CP, Chang YC.  The effects of self-management intervention among middle-age adults with knee osteoarthritis.. Journal of Advanced Nursing. Vol.72-No.08:1825-1837. Aug. 2016. (SCI/SCIE)
26. Huang CH, Lu YC, Chang TK, Hsiao IL, Su YC, Yeh ST, Fang SW, Huang CH.  In vivo biological response to highly cross-linked and vitamin e-doped polyethylene-a particle-Induced osteolysis animal study. Journal of biomedical materials research, part B. Vol.104-No.3:561-567. Apr. 2016. (SCI)
27. Chang TK, Hsu CC, Chen KT.  Optimal screw orientation for the fixation of cervical degenerative disc disease using nonlinear C3-T2 multi-level spinal models and neuro-genetic algorithms. Acta of Bioengineering and Biomechanics. Vol.17-No.3:59-66. Dec. 2015. (SCI)
28. Lu YC, Chang TK, Yeh ST, Fang HW, Lin CY, Hsu LI, Huang CH, Huang CH.  The potential role of strontium ranelate in treating particle-induced osteolysis. Acta Biomaterialia. Vol.20:147-154. Jul. 2015. (SCI)
29. Lai YS, Chen WC, Huang CH, Cheng CK, Chan KK, Chang TK*.  The Effect of Graft Strength on Knee Laxity and Graft In-Situ Forces after Posterior Cruciate Ligament Reconstruction. PLoS One. Vol.10-No.5:e0127293. May. 2015. (SCI/SCIE)
30. Huang CH, Hsu LI, Lin KJ, Chang TK, Cheng CK, Lu YC , Chen CS.  Patellofemoral Kinematics during deep knee flexion after total knee replacement - A computational simulation. Knee Surgery, Sports Traumatology, Arthroscopy. Vol.22-No.12:3047-3053. Dec. 2014. (SCI)
31. Hsu CC, Chang TK, Huy DC.  Biomechanical Comparison of Different Vertebral Plate Designs for Anterior Cervical Discectomy and Fusion Using Nonlinear C3-T2 Multi-Level Spinal Models. Computer-Aided Design and Applications. Vol.12-No.2:1-6. Oct. 2014. (EI)
32. Chen LP, Chang TK*, Huang TY, Kwok TK, Lu YC.  The correlation between lateral bowing angle of the femur and the location of atypical femur fractures. Calcified Tissue International. Vol.95-No.3:240-247. Sep. 2014. (SCI)
33. TK CHANG*, CH HUANG, YC LIU, WC CHEN, Colin J. McClean, YS LAI, CK CHENG.  Biomechanical evaluation and comparison of polyetheretherketone rod system to traditional titanium rod fixation on adjacent levels. Formosan Journal of Musculoskeletal Disorders. Vol.4-No.2:42-47. May. 2013. (其他具同儕審查機制之期刊)
34. MY CHUANG, TK CHANG, CH HUANG, TY HUANG.  Failure of the Rotating-Hinge Knee Megaprosthesis. The Journal of Arthroplasty. Vol.28-No.3:543-543. Mar. 2013. (SCI)
35. TK CHANG, CH HUANG, CH HUANG, HC CHEN, CK CHENG.  The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats. BMC Musculoskeletal Disorders. Vol.11:e185. Aug. 2010. (SCI/SCIE)
36. YC LU, CH HUANG, TK CHANG, CK CHENG, YH FANG, CH HUANG.  Wear pattern analysis in retrieved tibial inserts of mobile bearing and fixed bearing total knee prostheses. Journal of Bone and Joint Surgery [Br]. Vol.92:500-507. Apr. 2010. (SCI)
37. SF CHANG, TK CHANG, HH PENG, YT YEH, DY LEE, CR YEH, J Zhou, CK CHENG, CA CHANG, JJ CHIU.  BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Molecular Endocrinology. Vol.23-No.11:1827-1838. Nov. 2009. (SCI)

1. Ting-Kuo Chang*, Lei-Po Chen, Yueh-Ching Liu.  Staged Posterior Surgery in Severe and Rigid Scoliotic Curves without Anterior Release in a Mucopolysaccharidosis (MPS) Type II Patient. International Conference of Early Onset Scoliosis. Nov. 2018.
2. Ting Kuo Chang*.  Case discussion of spinal deformities. North Asia Spine Symposium and Academy. Nov. 2018.
3. Ting-Kuo Chang*, Yueh-Ching Liu, Lei-Po Chen.  Scoliosis after Thoracotomy in patients of Esophageal Atresia. Asia Pacific Spine Society 2018. Jun. 2018.
4. Huang CH, Hsu LI, Wu CY, Yeh ST, Chang TK, Lu YC, Huang CH.  Biomechanical analysis of different post-cam designs and material properties in posterior-stabilized total knee replacements. 2017 ORS Annual Meeting. Mar. 2017.
5. Huang CH， Hsu LI， Lu YC， Wu CY， Chang TK， Yeh ST， Huang CH。  Biomechanical analysis of different post-cam design features of posterior stabilized knee prostheses.. The 11th International Congress of Chinese Orthopaedic Association. 11月 2016.
6. Huang CH, Hsu LY, Lin KJ, Lu YC, Pu WH, Chang TK, Wei HW.  Morphometrical measurement of resected surface of anterior femoral condyle for Chinese population. 2015 ORS Annual Meeting. Mar. 2015.
7. Lu YC.  Biological response to highly cross-linked and vitamin e-doped polyethylene - A wear particle-induced osteolysis animal study. 2015 ORS Annual Meeting. Mar. 2015.

u647@mmc.edu.tw