馬偕醫學院 Mackay Medical College
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馬偕醫學院 Mackay Medical College
師資陣容  
李安生
(Lee, An-Sheng )
職稱 教授兼總務長
主要學歷

國立台灣大學藥理學研究所博士 (2001/9~2008/6) 
國立台灣大學藥學系學士 (1997/9~2001/6)
主要經歷

中國醫藥大學臨床醫學研究所助理教授 
中國醫藥大學附設醫院L5研究中心助理研究員暨實驗室經理 
中國醫藥大學附設醫院內科部心臟科助理研究員 
國立台灣大學醫學卓越研究中心博士後研究員 
國立台灣大學藥理學研究所博士後研究員 
美國加州大學洛杉磯分校(UCLA)生理學研究所研究助理
教學專長

生理學；藥理學
研究專長

心臟血管藥理學；細胞電生理學；脂蛋白學；心血管動物模式
學術期刊
  1. Wu MY, Lee AS, Lin YN, Chung WH, Chen KW, Lu CR, Chen YF, Chang CM, Tsai WC, Shiao YT, Chen CH, Chang KC.  Role of low-density lipoprotein electronegativity and sexual dimorphism in contributing early ventricular tachyarrhythmias following ST-elevation myocardial infarction. Frontiers in Cardiovascular Medicine. Vol.11:e1285068. Mar. 2024. (SCI/SCIE) ( SDGs3)
  2. Lee AS, Hung CL, Lai TS, Chung CH.  Investigation of the Therapeutic Potential of Organic Nitrates in Mortality Reduction Following Acute Myocardial Infarction in Hyperlipidemia Patients: A Population-Based Cohort Study. Journal of Personalized Medicine. Vol.14-No.1:124-124. Jan. 2024. (SCI/SCIE) ( SDGs3)
  3. Lin YK, Hsiao LC, Wu MY, Chen YF, Lin YN, Chang CM, Chung WH, Chen KW, Lu CR, Chen WY, Chang SS, Shyu WC, Lee AS*, Chen CH, Jeng LB, Chang KC.  PD-L1 and AKT overexpressing adipose-derived mesenchymal stem cells enhance myocardial protection by upregulating CD25+ T cells in acute myocardial infarction rat model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.25-No.1:e134. Dec. 2023. (SCI/SCIE) ( SDGs3)
  4. Lee AS, Sung YL, Pan SH, Sung KT, Su CH, Ding SL, Lu YJ, Hsieh CL, Chen YF, Liu CC, Chen WY, Chen XR, Chung FP, Wang SW, Chen CH, MR D, Hung CL, Yeh HI, Lin SF.  A Common East Asian Aldehyde Dehydrogenase 2*2 Variant Promotes Ventricular Arrhythmia with Chronic Light-to-Moderate Alcohol Use in Mice.. Communications Biology. Vol.6-No.1:e610. Jun. 2023. (SCI/SCIE) ( SDGs3)
  5. Chen PS, Feng WH, Tsai TH, Hong YK, Lee AS, Chang KC, Chung HC, Liu YW, Hsieh CC, Fang YH, Yang PJ, Luo CY, Liu PY, Cheng TL, Li YH.  Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling. Scientific Reports. Vol.12-No.1:e10532. Jun. 2022. (SCI/SCIE)
  6. Yu-Feng Hu, An-Sheng Lee, Shih-Lin Chang, Shien-Fong Lin, Ching-Hui Weng, Hsin-Yu Lo, Pei-Chun Chou, Yung-Nan Tsai, Yen-Ling Sung, Chien-Chang Chen, Ruey-Bing Yang, Yuh-Charn Lin, Terry B. J. Kuo, Cheng-Han Wu, Jin-Dian Liu, Tze-Wen Chung, Shih-Ann Chen.  Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats. Nature Biomedical Engineering. Vol.6-No.4:421-434. Apr. 2022. (SCI/SCIE)
  7. Hung CL, Sung KT, Chang SC, Liu YY, Kuo JY, Huang WH, Su CH, Liu CC, Tsai SY, Liu CY, Lee AS, Pan SH, Wang SW, Hou JY, Hung TC, Yeh HI.  Variant Aldehyde Dehydrogenase 2 (ALDH2*2) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians.. Biomolecules. Vol.11-No.11:e1559. Oct. 2021. (SCI/SCIE)
  8. Shiu-Jau Chen, Tzer-Bin Lin, Hsien-Yu Peng, Cheng-Hsien Lin, An-Sheng Lee, Hsiang-Jui Liu, Chun-Chieh Li, Kuang-Wen Tseng.  Protective Effects of Fucoxanthin Dampen Pathogen-Associated Molecular Pattern (PAMP) Lipopolysaccharide-Induced Inflammatory Action and Elevated Intraocular Pressure by Activating Nrf2 Signaling and Generating Reactive Oxygen Species. Antioxidants. Vol.10-No.7:e1092. Jul. 2021. (SCI/SCIE)
  9. Yung-Nan Tsai, Ya-Wen Hsiao, Shien-Fong Lin, Yi-Hsin Chan, Yu-Cheng Hsieh, Wei-Hua Tang, An-Sheng Lee, Yu-Ting Huang, Hsing‐Yuan Li, Tze-Fan Chao, Satoshi Higa, Tsu-Juey Wu, Shih-Lin Chang, Shih-ann Chen.  Proinflammatory Cytokine Modulates Intracellular Calcium Handling and Enhances Ventricular Arrhythmia Susceptibility. Frontiers in Cardiovascular Medicine. Vol.8:e623510. Mar. 2021. (SCI/SCIE)
  10. Shiu-Jau Chen, Tzer-Bin Lin, Hsien-Yu Peng, Hsiang-Jui Liu, An-Sheng Lee , Cheng-Hsien Lin, Kuang-Wen Tseng.  Cytoprotective Potential of Fucoxanthin in Oxidative Stress-Induced Age-Related Macular Degeneration and Retinal Pigment Epithelial Cell Senescence In Vivo and In Vitro. Marine Drugs. Vol.19(2):e0114-e0114. Feb. 2021. (SCI/SCIE)
  11. Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Hsueh-Hsiao Wang, Po-Sheng Yang, Jen-Kun Cheng, Gin-Den Chen, Soo-Cheen Ng, An-Sheng Lee, Kuang-Wen Tseng, Tzer-Bin Lin, Hsien-Yu Peng.  Blocking the Spinal Fbxo3/CARM1/K + Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief. Neurotherapeutics. Vol.18(2):1295-1315. Jan. 2021. (SCI/SCIE)
  12. Yanzhuo Ma, Nancy Cheng, Junping Sun, Jonathan Lu, Shahrzad Abbasi, Geru Wu, An-Sheng Lee, Tatsuya Sawamura, Jie Cheng, Chu-Huang Chen, Yutao Xi.  Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KATP channels through CaMKII activation. Lipids in Health and Disease. Vol.19:e189-e189. Aug. 2020. (SCI/SCIE)
  13. Po-Sheng Yang, Hsien-Yu Peng, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, An-Sheng Lee, Hsueh-Hsiao Wang, Yu-Cheng Ho.  NMDA receptor partial agonist GLYX-13 alleviates chronic stress-induced depression-like behavior through enhancement of AMPA receptor function in the periaqueductal gray. NEUROPHARMACOLOGY. Vol.178:e18269-e18269. Aug. 2020. (SCI/SCIE)
  14. Wei-Yu Chen, Yun-Fang Chen, Hua-Cheng Chan, Ching-Hu Chung, Hsien-Yu Peng, Yu-Cheng Ho, Chu-Huang Chen, Kuan-Cheng Chang, Chih-Hsin Tang, An-Sheng Lee*.  Role of apolipoprotein E in electronegative low-density lipoprotein-induced mitochondrial dysfunction in cardiomyocytes. METABOLISM-CLINICAL AND EXPERIMENTAL. Vol.107:e154227-e154227. Jun. 2020. (SCI/SCIE)
  15. Hua-Chen Chan, Hsiu-Chuan (Bonnie) Chan, Chan-Jung Liang, Hsiang-Chun Lee, Hung Su, An-Sheng Lee, Jentaie Shiea, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Chih-Sheng Chu, Richard A. Dixon, Liang-Yin Ke, Jeng-Hsien Yen, Chu-Huang Chen.  Role of low-density lipoprotein in early vascular aging associated with systemic lupus erythematosus.. Arthritis & Rheumatology. Vol.72-No.6:972-984. May. 2020. (SCI/SCIE)
  16. Yun-Fang Chen, An-Sheng Lee, Wei-Yu Chen, Chia-Hsin Lin, Chao-Lin Kuo, Jing-Gung Chung.  Partitioned Extracts of Bauhinia championii Induce G0/G1 Phase Arrest and Apoptosis in Human Colon Cancer Cellson cancer cell. AMERICAN JOURNAL OF CHINESE MEDICINE. Vol.48-No.3:719-736. Apr. 2020. (SCI/SCIE)
  17. Yun-Fang Chen, Wei-Yu Chen, Ching-Hu Chung, Chao-Lin Kuo, An-Sheng Lee*.  Cardiac protection of Bauhinia championii against reperfusion injury. ENVIRONMENTAL TOXICOLOGY. Vol.35(7):774-782. Feb. 2020. (SCI/SCIE)
  18. An-Sheng Lee, Yu-Chen Wang, Shih-Sheng Chang, Ping-Hang Lo, Chia-Ming Chang, Jonathan Lu, Alan R. Burns, Chu-Huang Chen, Akemi Kakino, Tatsuya Sawamura, Kuan-Cheng Chang.  Detection of a High Ratio of Soluble to Membrane-Bound LOX-1 in Aspirated Coronary Thrombi from Patients with ST-elevation Myocardial Infarction.. Journal of the American Heart Association. Vol.9(2):e14008-e14008. Jan. 2020. (SCI/SCIE)
  19. Chao-Hung Chen, Liang-Yin Ke, Hua-Chen Chan, Chih-Sheng Chu, An-Sheng Lee, Kun-Der Lin, Mei-Yueh Lee, Pi-Jung Hsiao, Chu-Huang Chen, Shyi-Jang Shin.  Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta via disruption of STRA6 cascade. Journal of Diabetes Investigation. Vol.11-No.3:535-544. Nov. 2019. (SCI/SCIE)
  20. Tsung-Jen Lin, Kuo-Chu Lai, An-Sheng Lee, Chien-Hsin Chang, Chiung-Lin Liu, Ching-Hu Chung.  Novel Antrodia cinnamomea extract reduced cancer stem-like phenotype changes and resensitized KRAS mutant colorectal cancer via a microRNA-27a pathway. Cancers. Vol.11-No.11:1657-1657. Oct. 2019. (SCI/SCIE)
  21. Chun-Cheng Wang, An-Sheng Lee, Shu-Hui Liu, Kuan-Cheng Chang, Ming-Yi Shen, Chiz-Tzung Chang.  Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model. BMC Nephrology. Vol.20-No.1:351-351. Sep. 2019. (SCI/SCIE)
  22. Hsiang‑Chun Lee, Yi‑Lin Shiou, Shih‑Jie Jhuo, Chia‑Yuan Chang, Po‑Len Liu, Wun‑Jyun Jhuang, Zen‑Kong Dai, Wei‑Yu Chen, Yun‑Fang Chen, An‑Sheng Lee*.  The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats. Cardiovascular Diabetology. Vol.18-No.1:45-45. Apr. 2019. (SCI/SCIE)
  23. Dylan Chou, Hsien-Yu Peng, Tzer-Bin Lin, Cheng-Yuan Lai, Ming-Chun Hsieh, Yang-Cheng Wen, An-Sheng Lee, Hsueh-Hsiao Wang, Po-Sheng Yang, Gin-Den Chen, Yu-Cheng Ho.  (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. NEUROPHARMACOLOGY. Vol.139:1-12. Sep. 2018. (SCI/SCIE)
  24. Yu-Chen Wang#, An-Sheng Lee#, Long-Sheng Lu, Liang-Yin Ke, Wei-Yu Chen, Jian-Wen Dong, Jonathan Lu, Zhenping Chen, Chih-Sheng Chu, Hua-Chen Chan, Taha Y. Kuzan, Ming-Hsien Tsai, Wen-Li Hsu, Richard A. F. Dixon, Tatsuya Sawamura, Kuan-Cheng Chang, Chu-Huang Chen.  Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. AGING CELL. Vol.17-No.4:1-11. Aug. 2018. (SCI/SCIE)
  25. Cheng-Yuan Lai, Ming-Chun Hsieh, Yu-Cheng Ho, Gin-Den Chen, Dylan Chou, Ting Ruan,, An-Sheng Lee, Hsueh-Hsiao Wang, Yat-Pang Chau, Hsien-Yu Peng, Cheng-Hung Lai.  GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription.. NEUROPHARMACOLOGY. Vol.135:536-546. Jun. 2018. (SCI/SCIE)
  26. Chien-Hsin Chang, Chun-Chieh Hsu, An-Sheng Lee, Wang SW, Kung-Tin Lin, Wei-Luen Chang, Hui-Chin Peng, Wen-Chiung Huang, Ching-Hu Chung.  4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression. BMC Complementary and Alternative Medicine. Vol.18:1-11. Mar. 2018. (SCI/SCIE)
  27. Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Hsueh-Hsiao Wang, An-Sheng Lee, Jen-Kun Cheng, Yat-Pang Chau, Hsien-Yu Peng.  Bromodomain-containing protein 4 activates voltage gated sodium channel 1.7 transcription in dorsal root ganglia neurons to mediate thermal hyperalgesia in rats (in press). ANESTHESIOLOGY. Vol.127-No.5:862-877. Nov. 2017. (SCI/SCIE)
  28. An-Sheng Lee, Yutao Xi, Chin-Hu Lai, Wei-Yu Chen, Hsien-Yu Peng, Hua-Chen Chan, Chu-Huang Chen, Kuan-Cheng Chang.  Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels. Scientific Reports. Vol.7-No.1:e10889-e10889. Sep. 2017. (SCI/SCIE)
  29. Chiz-Tzung Chang, Ming-Yi Shen, An-Sean Lee, Chun-Cheng Wang, Wei-Yu Chen, Chia-Ming Chang, Kuan-Cheng Chang, Nicole Stancel, Chu-Huang Chen.  Electronegative low-density lipoprotein increases the risk of ischemic lower-extremity peripheral artery disease in uremia patients on maintenance hemodialysis. Scientific Reports. Vol.7-No.1:4654-4654. Jul. 2017. (SCI/SCIE)
  30. Cheng-Yuan Lai, Ming-Chun Hsieh, Yu-Cheng Ho, An-Sheng Lee, Hsueh-Hsiao Wang, Jen-Kun Cheng, Yat-Pang Chau, Hsien-Yu Peng.  Growth arrest and DNA-damage-inducible protein 45 beta-mediated DNA demethylation of voltage-dependent T-type calcium channel 3.2 subunit enhances neuropathic allodynia after nerve injury in rats. ANESTHESIOLOGY. Vol.126-No.6:1077-1095. Jun. 2017. (SCI/SCIE)
  31. Chun‑Cheng Wang, Yao‑Chang Wang, Guei‑Jane Wang, Ming‑Yi Shen, Yen‑Lin Chang, Show‑Yih Liou, Hung‑Chih Chen, An‑Sheng Lee, Kuan‑Cheng Chang, Wei‑Yu Chen, Chiz‑Tzung Chang.  Skin autofluorescence is associated with inappropriate left ventricular mass and diastolic dysfunction in subjects at risk for cardiovascular disease. Cardiovascular Diabetology. Vol.16-No.1:e15. Jan. 2017. (SCI/SCIE)
  32. An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Ching-Hu Chung, Hsien-Yu Peng, Chia-Ming Chang, Ming-Jai Su, Chu-Huang Chen, Kuan-Cheng Chang.  Electronegative LDL-Mediated Cardiac Electrical Remodeling in a Rat Model of Chronic Kidney Disease. Scientific Reports. Vol.7:1-13. Jan. 2017. (SCI/SCIE)
  33. Chao-Hung Chen, Liang-Yin Ke, Hua-Chen Chan, An-Sheng Lee, Kun-Der Lin, Chih-Sheng Chu, Mei-Yueh Lee, Pi-Jung Hsiao, Chin Hsu, Chu-Huang Chen, Shyi-Jang Shin.  Electronegative Low-Density Lipoprotein Induces Renal Apoptosis and Fibrosis: STRA6 Signaling Involved. JOURNAL OF LIPID RESEARCH. Vol.57-No.8:1435-1446. Aug. 2016. (SCI/SCIE)
  34. Ming-Yi Shen, Fang-Yu Chen, Jing-Fang Hsu, Ru-Huei Fu, Chia-Ming Chang, Chiz-Tzung Chang, Chung-Hsiang Liu, Jia-Rong Wu, An-Sheng Lee, Hua-Chen Chan, Joen-Rong Sheu, Shinn-Zong Lin, Woei-Cherng Shyu, Tatsuya Sawamura, Kuan-Cheng Chang, Chung Y. Hsu, Chu-Huang Chen.  Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation. BLOOD. Vol.127-No.10:1336-1345. Mar. 2016. (SCI/SCIE)
  35. Chiz-Tzung Chang, Guei-Jane Wang, Chin-Chi Kuo, Ju-Yi Hsieh, An-Sean Lee, Chia-Ming Chang, Chun-Cheng Wang, Ming-Yi Shen, Chiu-Ching Huang, Tatsuya Sawamura, Chao-Yuh Yang, Nicole Stancel, Chu-Huang Chen.  Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in Uremia Patients on Maintenance Hemodialysis. MEDICINE. Vol.95-No.2:2265-2265. Jan. 2016. (SCI/SCIE)
  36. HONG-XUE JI, WEN-SHIN CHANG, CHIA-WEN TSAI, JU-YU WANG, NAI-KUEI HUANG, AN-SHENG LEE, MING-YI SHEN, WEI-YU CHEN, YAO-CHANG CHIANG, TZU-CHING SHIH, CHIN-MU HSU, DA-TIAN BAU.  Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotype to Gastric Cancer Risk in Taiwan. Anticancer Research. Vol.35:4975-4981. Sep. 2015. (SCI)
  37. Kuan-Cheng Chang#, An-Sheng Lee#, Wei-Yu Chen, Yen-Nien Lin, Jing-Fang Hsu, Hua-Chen Chan, Chia-Ming Chang, Shih-Sheng Chang, Chia-Chi Pan, Tatsuya Sawamura, Chi-Tzong Chang, Ming-Jai Su, Chu-Huang Chen.  Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction. Journal of Molecular and Cellular Cardiology. Vol.84:36-44. Apr. 2015. (SCI)
  38. Wei-Yu Chen, Fang-Yu Chen, An-Sheng Lee, Kuan-Hsiang Ting, Chia-Ming Chang, Jing-Fang Hsu, Wei-Shine Lee, Joen-Rong Sheu, Chu-Huang Chen, Ming-Yi Shen.  Sesamol Reduces LDL Electronegativity and Blocks Atherogenic L5 Signaling through LOX1. Journal of Natural Products. Vol.78:225-233. Feb. 2015. (SCI)
  39. Yi-Jin Ho, An-Sheng Lee, Wen-Pin Chen, Wei-Lung Chang, Ying-Kang Tsai, Hsi-Lin Chiu, Yueh-Hsiung Kuo, Ming-Jai Su.  Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovascular Diabetology. Vol.13:98-98. Jun. 2014. (SCI)
  40. An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Jin-Fang Hsu, Ming-Yi Shen, Chia-Ming Chang, Henry Bair, Ming-Jai Su, Kuan-Cheng Chang, Chu-Huang Chen.  Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL. Cardiovascular Diabetology. Vol.13:64-64. Mar. 2014. (SCI)
  41. Hua-Chen Chan, Liang-Yin Ke, Chih-Sheng Chu, An-Sheng Lee, Ming-Yi Shen, Miguel A. Cruz, Jin-Fang Hsu, Kai-Hung Cheng, Hsiu-Chuan Bonnie Chan, Jonathan Lu, Wen-Ter Lai, Tatsuya Sawamura, Sheng-Hsiung Sheu, Jeng-Hsien Yen, Chu-Huang Chen.  Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. Vol.122-No.22:3632-3641. Nov. 2013. (SCI)
  42. Yi-Jin Ho, Wen-Pin Chen, Tzong-Cherng Chi, Ching-Chia Chang Chien, An-Sheng Lee, Hsi-Lin Chiu, Yueh-Hsiung Kuo, Ming-Jai Su.  Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats.. Cardiovascular Diabetology. Vol.12-No.1:99-99. Jul. 2013. (SCI)
  43. An-Sheng Lee, Wen-Pin Chen, Yu-Lin Kuo, Yi-Jin Ho, Shoei-Sheng Lee , Ming-Jai Su.  Thaliporphine Preserves Cardiac Function of Endotoxemic Rabbits by Both Directly and Indirectly Attenuating NFkB Signaling Pathway. PLoS One. Vol.7-No.6:39174-39183. Jun. 2012. (SCI)
  44. Ching-Yi Chen, Hsiu-Ching Hsu, An-Sheng Lee, Daming Tang, Lu-Ping Chow, Chao-Yuh Yang, Han Chen, Yuan-Teh Lee, Chu-Huang Chen.  The most negatively charged low-density lipoprotein L5 induces stress pathways in vascular endothelial cells.. Journal of Vascular Research. Vol.49-No.4:329-341. May. 2012. (SCI)
  45. An-Sheng Lee, Guei-Jane Wang, Hua-Chen Chan, Fang-Yu Chen, Chia-Ming Chang, Chao-Yuh Yang, Yuan-Teh Lee, Kuan-Cheng Chang, Chu-Huang Chen.  Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell–released chemokines.. Apoptosis. Vol.17-No.9:1009-1018. May. 2012. (SCI)
  46. Li-Shian Shi, Yu-Ren Liao, Ming-Jai Su, An-Sheng Lee, Ping-Chung Kuo, Amooru G. Damu, Sheng-Chu Kuo, Han-Dong Sun, Kuo-Hsiung Lee, Tian-Shung Wu.  Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity. Journal of Natural Products. Vol.73-No.7:1214-1222. Jun. 2010. (SCI)
  47. An-Sheng Lee, Wen-Pin Chen, Ming-Jai Su.  Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin. Journal of Biomedical Science. Vol.15-No.4:519-528. Apr. 2008. (SCI)
  48. Kwang-Ming Fang#, An-Sheng Lee#, Ming-Jai Su, Chien-Liang Lin, Chung-Liang Chien, Mei-Lin Wu.  Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. Cardiovascular Research. Vol.78-No.3:533-545. Feb. 2008. (SCI)
  49. An-Sheng Lee, Ming-Jai Su.  Comparison of the cardiac effects between quinazoline-based alpha1- adrenoceptor antagonists on occlusion-reperfusion injury.. Journal of Biomedical Science. Vol.15-No.2:239-249. Jan. 2008. (SCI)
  50. An-Sheng Lee, Tian-Shung Wu, Ming-Jai Su.  Pharmacological profile of the new inotropic agent AT-11. European Journal of Pharmacology. Vol.580-No.1:224-230. Jan. 2008. (SCI)
研討會
  1. Chang KC, Wu MY, Lin YN, Lee AS, Chen CH.  LDL electronegativity and male predominance in early ventricular tachyarrhythmias following ST-elevation myocardial infarction: evidence of sexual dimorphism associated reduction of sodium currents.. ESC Congress 2023. Aug. 2023.
  2. An-Sheng Lee*, Yun-Fang Chen, Wei-Yu Chen.  Role of Glycine N-methyltransferase in electronegative lipoproteins-induced vascular dysfunction in a diabetic rodent model.. American Diabetes Association’s 83rd Scientific Sessions. Jun. 2023.
  3. Yu-Kai Lin, An-sheng Lee, Mei-Yao Wu, Chia-Ming Chang, Yun-Fang Chen, Yen-Nien Lin, Wei-Yu Chen, Woei-Cherng Shyu, Lien-Cheng Hsiao, Kuan-Cheng Chang.  Adipose-Derived Mesenchymal Stem Cells Overexpressing PD-L1 and Akt Confer Myocardial Protection Through Upregulation of CD25+ T Cells in a Rat Model of Acute Myocardial Infarction. American Heart Association's Scientific Sessions 2022. Nov. 2022.
  4. Yun-Fang Chen, Wei-Yu Chen, An-Sheng Lee*.  Atherogenic lipoprotein causes cardiac dysfunction through inducing ROS-dependent coronary vascular hyperpermeability. The 10th Biennial Meeting of Society for Free Radical Research-Asia. Nov. 2022.
  5. Hua-Chen Chan, Hsiu-Chuan Chan, Chan-Jung Liang, Hsiang-chun Lee, Hung Su, An-sheng Lee, Jentaie Shiea.  Role of Low-Density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus. American Heart Association Scientific Sessions 2019. Nov. 2019.
  6. An-Sheng Lee, Chung-Lieh Hung, Cheng-Huang Su, Hung-I Yeh.  Effects of moderate alcohol ingestion on cardiac electromechanical properties in Asia-specific aldehyde dehydrogenase 2 deficiency mice. American Heart Association Scientific Sessions 2019. Nov. 2019.
  7. Hsiang-Chun Lee, Yi-Lin Shiou, Shih-Jie Jhuo, Chia-Yuan Chang, Po-Len Liu, Wun-Jyun Jhuang, An-Sheng Lee*.  The Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin Exhibits Cardiac and Renal Protection in Hypertensive Heart Failure Rats. American Heart Association Scientific Session 2018. Nov. 2018.
  8. Yun-Fang Chen, Wei-Yu Chen, Chia-Hsin Lin, Chao-Lin Kuo, An-Sheng Lee*.  Protection of Bauhinia championii on Ischemia/Reperfusion-Induced Cardiac Dysfunction. 18th World Congress of Basic and Clinical Pharmacology. Jul. 2018.
  9. Wei-Yu Chen, Chih-Hsin Tang, Yun-Fang Chen, Chin-Hu Lai, Chu-Huang Chen, An-Sheng Lee*.  Effect of Monascus Purpureus Rice on Electronegative LDL-Induced Mitochondrial Dysfunction in Cardiomyocytes. 18th World Congress of Basic and Clinical Pharmacology. Jul. 2018.
  10. An-Sheng Lee*, Chin-Hu Lai, Wei-Yu Chen, Tzu-Yu Hsu, Chu-Huang Chen.  Electronegative LDL-mediated QTc prolongation in elderly patients with metabolic syndrome. Aging and Mechanisms of Aging‐Related Disease. May. 2017.
  11. Kuan-Cheng Chang, An-Sheng Lee, Wei-Yu Chen, Chu-Huang Chen.  Chronic Kidney Disease Disrupting Transmural Gradient of Transient Outward Potassium Current via Downregulation of KChIP2 May Promote Susceptibility to Ventricular Tachyarrhythmias. American Heart Association Scientific Sessions 2016. Nov. 2016.
  12. An-Sheng Lee, Wei-Yu Chen, Ching-Hu Lai, Tzu-Yu Hsu, Chu-Huang Chen.  Increased electronegative low-density lipoprotein in type 2 diabetes promotes cardiac dysfunction through inducing endothelial hyperpermeability. American Diabetes Association 76th Scientific Sessions 2016. Jun. 2016.
  13. Hua-Chen Chan, Liang-Yin Ke, Hsiu-Chuan Chan, Hung Su, An-Sheng Lee, Jonathan Lu, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Chih-Sheng Chu, Jentaie Shiea, Jeng-Hsien Yen, Chu-Huang Chen.  Low-density lipoprotein of systemic lupus erythematosus patients contains lysophosphatidylcholine-rich lipid that induces overexpression of CX3CL1 in endothelial cells. American Heart Association Scientific Sessions 2014. Nov. 2014.
  14. Ming-Yi Shen, Fang-Yu Chen, An-Sheng Lee, Joen-Rong Sheu, Tatsuya Sawamura, Richard A Dixon, Chung Y Hsu, Chu-Huang Chen.  Silencing miR-145 Prevents Potentiating Effects of Human Electronegative Low- Density Lipoprotein on Platelet Activation. American Heart Association Scientific Sessions 2013. Nov. 2013.
  15. An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Ming-Yi Shen, Yu-Chen Wang, Long-Sheng Lu, Jonathan Lu, Tatsuya Sawamura, Chu-Huang Chen.  Electronegative low-density lipoprotein induces endothelial DNA damage and senescence in vivo. American Heart Association Scientific Sessions 2013. Nov. 2013.
  16. Yu-Chen Wang, Long-Sheng Lu, Jian-Wen Dong, Jonathan Lu, An-Sheng Lee, Shu-Hua Chen, Hong Dou, Taha Y Kuzan, Kuan-Cheng Chang, Richard AF Dixon, Chu-Huang Chen.  The DNA Damage Response Mediates Endothelial Cell Senescence Induced by Electronegative LDL. American Heart Association Scientific Sessions 2012. Nov. 2012.
  17. Hua-Chen Chan, Liang-Yin Ke, Chin-Sheng Chu, An-Sheng Lee, Ming-Yi Shen, Miguel A Cruz Cruz, Kai- Hung Cheng, Hsiu-Chuan Chan, Wen-Ter Lai, Jeng-Hsien Yen, Chu-Huang Chen.  Highly Electronegative LDL is Elevated in Patients With Acute Myocardial Infarction and Triggers Platelet Activation and Aggregation. American Heart Association Scientific Sessions 2012. Nov. 2012.
  18. An-Sheng Lee, Fang-Yu Chen, Shih-Sheng Chang, Hua-Chen Chan, Chi-Tzong Chang, Ming-Jai Su, Chu-Huang Chen, Kuan-Cheng Chang.  Mechanisms of Cardiac Diastolic Dysfunction in a Model of Cardiorenal Syndrome. American Heart Association Scientific Sessions 2012. Nov. 2012.
  19. An-Sheng Lee, Jenny Wang, Hua-Chen Chan, Fang-Yu Chen, Chia-Ming Chang, Chao-yuh Yang, Kuan-Cheng Chang, Chu-Huang Chen.  Electronegative low-density lipoprotein induces cardiomyocyte apoptosis through a chemokine-cytokine crosstalk mechanism. American College of Cardiology Scientific Sessions 2012. Mar. 2012.
  20. Kuan-Chen Chang, Shih-Sheng Chang, Hsin-Yueh Liang, An-Sheng Lee, Ming-Jai Su.  Chronic single nephrectomy prolongs action potential duration by inhibiting transient outward currents in left ventricular myocytes.. Cardiac Electrophysiology Society-Annual Meeting. Nov. 2009.
  21. An-Sheng Lee, Ming-Jai Su.  Comparison of two alpha1-blockers bunazosin and doxazosin on electrophysiologic effects. International Congress on Coronary Artery Disease. Oct. 2007.
  22. Ming-Jai Su, Wei-Lun Chang, An-Sheng Lee.  Investigation medical therapy in heart failure. International Congress on Cardiovascular Disease. Nov. 2004.
  23. An-Sheng Lee, Tian-Shung Wu, Ming-Jai Su.  Pharmacological profile of the new inotropic agent AT-11. Pharmaceutical Sciences World Congress. May. 2004.
計畫
計畫起訖年月計畫名稱擔任職務
2024-08~2025-07113學年度國科會管理費-總務處主持人
2024-01~2024-12113年教育部補助各級公私立學校校園綠籬專案計畫主持人
2023-09~2024-12產學合作計畫(D)_COFxMMC-RD-112-1D-P004_李安生_心血管藥物治療之療效評估主持人
2023-08~2024-07112學年度國科會管理費-總務處主持人
2023-08~2024-07校外研究計畫獎助款(B)_MMC-RD-112-1B-P029_李安生主持人
2023-01~2023-12112年教育部補助各級公私立學校校園綠籬專案計畫主持人
2022-08~2023-07111學年度國科會管理費-總務處主持人
2022-08~2023-07血管張力素受體-腦啡肽酶抑制劑(ARNi)在心肌梗塞相關之心衰竭所扮演之腳色:由基礎到臨床/ARNI 對收縮性心衰竭心肌梗塞小鼠模型的治療潛力主持人
2022-08~2023-07校外研究計畫獎助款(B)_MMC-RD-111-1B-P025_李安生主持人
2022-08~2025-07探討菊花木活性成分對脂質異常引發心臟功能受損之保護作用主持人
2021-08~2022-07110學年度管理費-總務處主持人
2021-08~2022-07有機硝酸鹽類藥物組合對於改善心肌缺血/再灌注損傷後心血管功能的風險及療效評估：以心肌缺血再灌流小鼠模式評估有機硝酸鹽類藥物之治療潛力主持人
2021-08~2022-07校外產學計畫相對獎助款(E)_MMC-RD-110-1E-P002_李安生主持人
2021-08~2022-07探討菊花木萃取物對陰電性低密度脂蛋白所導致之心臟功能受損的保護作用主持人
2020-08~2021-07109學年度管理費-總務處主持人
2020-08~2021-07市售藥物改善心肌缺血/再灌注損傷後心血管功能的治療潛力研究:以高血脂患者為例-以心肌缺血再灌流小鼠模式評估市售心肌梗塞藥物之治療潛力主持人
2020-08~2021-07校外研究計畫獎助款(B)_1091B18_李安生主持人
2020-08~2024-07產學合作計畫(D)_1091D01_李安生_死亡率與麻醉方式、麻醉危險因子及醫療器材使用之相關性研究主持人
2020-02~2020-07校外研究計畫獎助款(B)_1082B02_李安生主持人
2019-08~2020-07校外計畫獎助款_李安生_1081B33主持人
2018-08~2019-07校外研究計畫獎助款_李安生_1071B01主持人
2018-08~2021-07探討蒿屬植物萃取物對陰電性脂蛋白所導致之血管老化的保護作用主持人
2017-08~2018-07校外研究計畫獎助款_李安生_1061B23主持人
2017-07~2018-06探討陰電性低密度脂蛋白對心肌細胞膜上離子通道功能之影-護理系二年級彭柏瑄主持人
2016-08~2017-07校外研究計畫獎助款_李安生 _1051B11主持人
2015-08~2018-07利用細胞膜鉗定技術探討陰電性脂蛋白在心肌梗塞後心室心律不整所扮演之電生理角色與中草藥治療(2/3)主持人
2014-08~2015-07Study of coronary hyperpermeability as a novel mechanism of lipid-induced cardiac dysfunction主持人
2014-01~2016-12A translational study of apolipoprotein CIII-mediated cardiorenal syndrome共同主持人
2013-01~2013-12Stroke Biosignature Project共同主持人
專書
出刊日期專書書名作者
2017-10新圖解生理學林則彬;
2017-04護理藥理學吳文彬;
組織
擔任期間機構職務
2022-03-22 ~
2024-11-18		社團法人台灣自由基學會秘書長
編審
期間期刊名稱性質
2024-03-11 ~
2024-04-07		The Kaohsiung Journal of Medical Sciences審查委員
榮譽
期間榮譽名稱舉辦國家
2019-08-01 ~
2020-07-31		109學年度教學優良教師台灣
2016-07-01 ~
2016-08-31		105學年度第三屆研究創作獎台灣
2015-08-01 ~
2016-07-31		105學年度教學傑出教師台灣
2015-08-01 ~
2016-07-31		105學年度第二屆研究創作獎台灣
榮譽獎

國科會菁英專案擴增留學計畫(2006-2007)
個人興趣

球類、運動、唱歌、旅行
聯絡方式

anshenglee@mmc.edu.tw
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馬偕醫學院 醫學系 MacKay Medical College Department of Medicine
辦公位址：新北市三芝區中正路三段46號 教學大樓B棟五樓
電話：(02)26360303 #1201　電子郵件：cindy@mmc.edu.tw
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