國立中興大學博士
中山醫學大學碩士

中國醫藥大學醫學系生理學科兼任助理教授
中國醫藥大學附設醫院泌尿部助理研究員
國立台灣大學附設醫院外科部博士後研究員

感覺神經生理學、泌尿生理學

神經塑性、疼痛機轉

1. Yeh CM, Lai CY, Peng HY, Lin TB, Chou D, Wang HH, Yang PS, Cheng JK, Peng YC, Hsieh MC.  Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion. ANESTHESIA AND ANALGESIA. Vol.138(5):1107-1119. May. 2024. (SCI/SCIE)
2. Li Z, Peng HY, Lee CS, Lin TB, Hsieh MC,  Lai CY, Wu HF, Chen LC, Chen MC,  Chou D.  Methylone produces antidepressant-relevant actions and prosocial effects. NEUROPHARMACOLOGY. Vol.242:e109787. Jan. 2024. (SCI/SCIE)
3. Li Z, Lee CS, Chen S, He B, Chen X, Peng HY,  Lin TB, Hsieh MC, Lai CY, Chou D.  Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala. Neurobiology of Stress. Vol.28:e100600. Jan. 2024. (SCI/SCIE)
4. Hsieh MC, Lai CY, Cho WL, Lin LT, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST, Lin TB, Peng HY*.  Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain. ANESTHESIA AND ANALGESIA. Vol.137(6):1289-1301. Dec. 2023. (SCI/SCIE)
5. Hsieh MC, Lai CY, Lin LT, Chou D, Yeh CM, Cheng JK, Wang HH, Lin KH, Lin TB, Peng HY*.  Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons. ACS Chemical Neuroscience. Vol.14(23):4227-4239. Dec. 2023. (SCI/SCIE)
6. Li Z, Xu Y, Li R, Sheng Z, Chen X, Liu X, Lee CS, Peng HY, Lin TB, Hsieh MC, Lai CY, Wu HF, Chou D.  BTRX-246040 Acts Through the Ventrolateral Periaqueductal Gray to Exert Antidepressant-Relevant Actions in Mice. International Journal of Neuropsychopharmacology. Vol.26(7):483-495. Jul. 2023. (SCI/SCIE)
7. Lau HH,  Lai CY, Hsieh MC, Peng HY, Chou D, Su TH, Lee JJ, Lin TB.  Pressure-Volume Loop Analysis of Voiding Workload: An Application in Trans-Vaginal Mesh-Repaired Pelvic Organ Prolapse Patients. BioengineeringBioengineering-Basel. Vol.10(7):853-853. Jul. 2023. (SCI/SCIE)
8. Hsieh MC,  Lai CY, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST,  Lin TB,  Peng HY*.  Phosphorylated Upstream Frameshift 1–dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia–like Behavior in Rats. ANESTHESIOLOGY. Vol.138(6):634-655. Jun. 2023. (SCI/SCIE)
9. Lin KH, Li JY, Chen RJ, Chen TY, Hsu SH, Wang HH, Peng HY, Sun YY, Lu WJ.  Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis. THROMBOSIS RESEARCH. Vol.225:63-72. May. 2023. (SCI/SCIE)
10. Xu Y, Yu Z, Chen S, Li Z, Long X, Chen M, Lee CS, Peng HY, Lin TB, Hsieh MC, Lai CY, Chou D.  (2R,6R)-hydroxynorketamine targeting the basolateral amygdala regulates fear memory. NEUROPHARMACOLOGY. Vol.225:e109402. Mar. 2023. (SCI/SCIE)
11. Lu WJ, Tsai CH, Chen RJ, Huang LT, Chen TY, Chen LC, Wang HH, Peng HY, Sun YY, Lin KH .  Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. BIOMEDICINE & PHARMACOTHERAPY. Vol.153:e113531. Sep. 2022. (SCI/SCIE)
12. Lau HH, Lai CY, Peng HY, Hsieh MC, Su TH, Lee JJ, Lin TB .  Modification of bladder thermodynamics in stress urinary incontinence patients submitted to trans-obturator tape: A retrospective study based on urodynamic assessment. Frontiers in bioengineering and biotechnology. Vol.10:e912602. Aug. 2022. (SCI/SCIE)
13. Lai CY, Hsieh MC, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST,  Lin TB, Peng HY*.  MicroRNA-489-3p attenuates neuropathic allodynia by regulating oncoprotein DEK/TET1-dependent epigenetic modification in the dorsal horn. NEUROPHARMACOLOGY. Vol.210:e109028. Jun. 2022. (SCI/SCIE)
14. Shih TL, Lin KH, Chen RJ, Chen TY, Kao WT, Liu JW, Wang HH, Peng HY, Sun YY, Lu WJ.  A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.25(19):9434-9446. Oct. 2021. (SCI/SCIE)
15. Hsieh CM, Lin WC, Peng HY, Chen HC, Ho YC, Li CJ, Wu XG, Chung JY,  Lee SD, Lin TB.  Shoulder transcutaneous electric nerve stimulation decreases heart rate via potentiating vagal tone. Scientific Reports. Vol.11(1):e19168. Sep. 2021. (SCI/SCIE)
16. Wang HH, Lin CJ, Tseng YM, Lee HI,  Lee YN, Yeh HI, Yang PS, Peng HY, Wu YJ.  Dihydrolipoic acid-coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway. Nanomedicine-Nanotechnology Biology and Medicine. Vol.36:e102427. Aug. 2021. (SCI/SCIE)
17. Chen SJ, Lin TB,  Peng HY, Lin CH,  Lee AS,  Liu HJ, Li CC, Tseng KW.  Protective Effects of Fucoxanthin Dampen Pathogen-Associated Molecular Pattern (PAMP) Lipopolysaccharide-Induced Inflammatory Action and Elevated Intraocular Pressure by Activating Nrf2 Signaling and Generating Reactive Oxygen Species. Antioxidants. Vol.10(7):e1092. Jul. 2021. (SCI/SCIE)
18. Peng HY,  Lai CY, Hsieh MC, Lin TB.  Solifenacin/Mirabegron Induces an Acute Compliance Increase in the Filling Phase of the Capacity-Reduced Urinary Bladder: A Pressure-Volume Analysis in Rats. Frontiers in Pharmacology. Vol.12:e657959. May. 2021. (SCI/SCIE)
19. Hsieh MC, Ho YC, Lai CY, Wang HH, Yang PS, Cheng JK, Chen GD, Ng SC, Lee AS, Tseng KW, Lin TB, Peng HY*.  Blocking the Spinal Fbxo3/CARM1/K + Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief. Neurotherapeutics. Vol.18(2):1295-1315. Apr. 2021. (SCI/SCIE)
20. Chen SJ, Lin TB, Peng HY, Liu HJ, Lee AS, Lin CH, Tseng KW.  Cytoprotective Potential of Fucoxanthin in Oxidative Stress-Induced Age-Related Macular Degeneration and Retinal Pigment Epithelial Cell Senescence In Vivo and In Vitro. Marine Drugs. Vol.19(2):e114. Feb. 2021. (SCI/SCIE)
21. Yang PS, Peng HY, Lin TB, Hsieh MC, Lai CY, Lee AS, Wang HH, Ho YC.  NMDA receptor partial agonist GLYX-13 alleviates chronic stress-induced depression-like behavior through enhancement of AMPA receptor function in the periaqueductal gray. NEUROPHARMACOLOGY. Vol.178:e108269. Nov. 2020. (SCI/SCIE)
22. Lin TB, Lai CY, Hsieh MC, Ho YC, Wang HH, Yang PS, Cheng JK, Chen GD, Ng SC,  Peng HY*.  Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription. PAIN. Vol.161(9):1995-2009. Sep. 2020. (SCI/SCIE)
23. Lien LM, Lu WJ, Chen TY,  Lee TY, Wang HH, Peng HY, Chen RJ, Lin KH.  Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.20(18):6954-6954. Sep. 2020. (SCI/SCIE)
24. Chen WY, Chen YF, Chan HC, Chung CH, Peng HY, Ho YC, Chen CH, Chang KC, Tang CH, Lee AS.  Role of apolipoprotein E in electronegative low-density lipoprotein-induced mitochondrial dysfunction in cardiomyocytes. METABOLISM-CLINICAL AND EXPERIMENTAL. Vol.107:e154227-e154227. Jun. 2020. (SCI/SCIE)
25. Peng HY, Lai CY, Hsieh MC, Ho YC, Lin TB.  Pressure-volume analysis of rat's micturition cycles in vivo. NEUROUROLOGY AND URODYNAMICS. Vol.39(5):1304-1312. Jun. 2020. (SCI/SCIE)
26. Hsieh MC, Peng HY, Ho YC, Lai CY, Cheng JK, Chen GD, Lin TB.  Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.20(17):4177-4177. Aug. 2019. (SCI/SCIE)
27. Chen SJ, Lee CJ, Lin TB, Peng HY, Liu HJ, Chen YS, Tseng KW.  Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model. Marine Drugs. Vol.17(3):1-14. Mar. 2019. (SCI/SCIE)
28. Lai CY, Hsieh MC, Ho YC, Wang HH, Chou D, Wen YC, Yang PS, Cheng JK, Peng HY*.  Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates mGluR5 Transcription for Neuropathic Allodynia. JOURNAL OF NEUROSCIENCE. Vol.38(48):9160-9174. Oct. 2018. (SCI/SCIE)
29. Chou D,  Peng HY, Lin TB, Lai CY, Hsieh MC,  Wen YC, Lee AS, Wang HH, Yang PS, Chen GD, Ho YC.  (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. NEUROPHARMACOLOGY. Vol.139:1-12. Sep. 2018. (SCI/SCIE)
30. Hsieh MC, Ho YC, Lai CY, Chou D, Chen GD, Lin TB,  Peng HY*.  Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats. Cell Death & Disease. Vol.9(8):811-811. Jul. 2018. (SCI/SCIE)
31. Lai CY, Hsieh MC, Ho YC, Chen GD, Chou D, Ruan T, Lee AS, Wang HH, Chau YP, Peng HY, Lai CH.  GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. NEUROPHARMACOLOGY. Vol.135:536-546. Jun. 2018. (SCI/SCIE)
32. Ho YC, Lin TB, Hsieh MC,  Lai CY, Chou D, Chau YP, Chen GD, Peng HY*.  Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression. NEUROPSYCHOPHARMACOLOGY. Vol.43(2):302-312. Jan. 2018. (SCI/SCIE)
33. Hsieh MC, Ho YC, Lai CY, Chou D, Wang HH, Chen GD, Lin TB, Peng HY*.  Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain. JOURNAL OF PINEAL RESEARCH. Vol.63(4):1-17. Nov. 2017. (SCI/SCIE)
34. Hsieh MC, Ho YC, Lai CY, Wang HH,  Lee AS, Cheng JK, Chau YP, Peng HY*.  Bromodomain-containing Protein 4 Activates Voltage-gated Sodium Channel 1.7 Transcription in Dorsal Root Ganglia Neurons to Mediate Thermal Hyperalgesia in Rats. ANESTHESIOLOGY. Vol.127(5):862-877. Nov. 2017. (SCI/SCIE)
35. Lee AS, Xi Y, Lai CH, Chen WY, Peng HY, Chan HC, Chen CH, Chang KC.  Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels. Scientific Reports. Vol.7(1):e10889-e10889. Sep. 2017. (SCI/SCIE)
36. Shiue SJ, Peng HY, Lin CR, Wang SW, Rau RH, Cheng JK.  Continuous Intrathecal Infusion of Cannabinoid Receptor Agonists Attenuates Nerve Ligation-Induced Pain in Rats. Regional Anesthesia and Pain Medicine. Vol.42(4):499-506. Jul. 2017. (SCI/SCIE)
37. Lai CY, Hsieh MC, Ho YC, Lee AS, Wang HH, Cheng JK, Chau YP,  Peng HY*.  Growth Arrest and DNA-damage-inducible Protein 45β-mediated DNA Demethylation of Voltage-dependent T-type Calcium Channel 3.2 Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats. ANESTHESIOLOGY. Vol.126(6):1077-1095. Jun. 2017. (SCI/SCIE)
38. Lee AS, Chen WY, Chan HC, Ching-Hu Chung, Peng HY, Chang CM, Su MJ, Chang KC.  Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease. Scientific Reports. Vol.7:40676-40676. Jan. 2017. (SCI/SCIE)
39. Hsieh MC, Lai CY, Ho YC, Wang HH, Cheng JK, Chau YP, Peng HY*.  Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats. Scientific Reports. Vol.6:37411-37411. Nov. 2016. (SCI/SCIE)
40. Lai CY, Ho YC, Hsieh MC, Wang HH, Cheng JK, Chau YP, Peng HY*.  Spinal Fbxo3-Dependent Fbxl2 Ubiquitination of Active Zone Protein RIM1α Mediates Neuropathic Allodynia through CaV2.2 Activation. JOURNAL OF NEUROSCIENCE. Vol.36(37):9722-9738. Sep. 2016. (SCI/SCIE)
41. Lin TB, Hsieh MC,  Lai CY, Cheng JK, Wang HH, Chau YP, Chen GD, Peng HY*.  Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. JOURNAL OF PINEAL RESEARCH. Vol.60(3):263-276. Apr. 2016. (SCI/SCIE)
42. Lai CY, Lin TB, Hsieh MC, Chen GD, Peng HY*.  SIRPα1-SHP2 Interaction Regulates Complete Freund Adjuvant-Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats. ANESTHESIA AND ANALGESIA. Vol.122(3):871-881. Mar. 2016. (SCI/SCIE)

hypeng@mmc.edu.tw